Manipulation of the recipient retinal environment by ectopic expression of neurotrophic growth factors can improve transplanted photoreceptor integration and survival.

@article{West2012ManipulationOT,
  title={Manipulation of the recipient retinal environment by ectopic expression of neurotrophic growth factors can improve transplanted photoreceptor integration and survival.},
  author={E L West and Rachael A. Pearson and Yana{\'i} Dur{\'a}n and Anai Gonzalez-Cordero and Robert E MacLaren and Alexander J. Smith and Jane C. Sowden and Robin R Ali},
  journal={Cell transplantation},
  year={2012},
  volume={21 5},
  pages={
          871-87
        }
}
Degeneration of the neural retina is the leading cause of untreatable blindness in the developed world. Stem cell replacement therapy offers a novel strategy for retinal repair. Postmitotic photoreceptor precursors derived from the early postnatal (P) retina are able to migrate and integrate into the adult mouse retina following transplantation into the subretinal space, but it is likely that a large number of these cells would be required to restore vision. The adult recipient retina presents… CONTINUE READING
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