Manipulation of serotonin signal suppresses early phase of behavioral aging in Caenorhabditis elegans

@article{Murakami2008ManipulationOS,
  title={Manipulation of serotonin signal suppresses early phase of behavioral aging in Caenorhabditis elegans},
  author={Hana Murakami and Karalee Bessinger and J. Hellmann and S. Murakami},
  journal={Neurobiology of Aging},
  year={2008},
  volume={29},
  pages={1093-1100}
}
  • Hana Murakami, Karalee Bessinger, +1 author S. Murakami
  • Published 2008
  • Biology, Medicine
  • Neurobiology of Aging
  • Aging is associated with progressive changes in behavioral functions, in part caused by muscle frailty, called sarcopenia. However, it was not clear whether certain neurotransmitters are directly involved in behavioral aging. Here we investigated aging of locomotion behaviors with an associative learning property, called basal and enhanced slowing response in Caenorhabditis elegans. Basal slowing response is a modest slowdown in response to food, while enhanced slowing response is a greater… CONTINUE READING
    30 Citations

    Topics from this paper

    Bilobalide modulates serotonin-controlled behaviors in the nematode Caenorhabditis elegans
    • 11
    EGF signaling comes of age: Promotion of healthy aging in C. elegans
    • 22
    Serotonin: from top to bottom
    • 76

    References

    SHOWING 1-10 OF 32 REFERENCES
    Behavioral deficits during early stages of aging in Caenorhabditis elegans result from locomotory deficits possibly linked to muscle frailty.
    • 118
    • PDF
    The effects of aging and oxidative stress on learning behavior in C. elegans
    • 72
    Feeding status and serotonin rapidly and reversibly modulate a Caenorhabditis elegans chemosensory circuit.
    • 209
    • PDF
    Measurements of age-related changes of physiological processes that predict lifespan of Caenorhabditis elegans.
    • 376
    • PDF
    Serotonin regulates repolarization of the C. elegans pharyngeal muscle
    • 95
    • PDF
    Serotonin-deficient mutants and male mating behavior in the nematode Caenorhabditis elegans
    • C. Loer, C. Kenyon
    • Biology, Medicine
    • The Journal of neuroscience : the official journal of the Society for Neuroscience
    • 1993
    • 254
    • PDF