Manipulation of serotonin signal suppresses early phase of behavioral aging in Caenorhabditis elegans

  title={Manipulation of serotonin signal suppresses early phase of behavioral aging in Caenorhabditis elegans
  author={Hana Murakami and Karalee Bessinger and Jason Hellmann and Shin Murakami},
  journal={Neurobiology of Aging},
Longevity Manipulations Differentially Affect Serotonin/Dopamine Level and Behavioral Deterioration in Aging Caenorhabditis elegans
It is reported that serotonin (5-HT) and dopamine (DA) level decrease with age in C. elegans, and it is found that elevating 5-HT/DA ameliorates age-related deterioration of pharyngeal pumping, food-induced slowing responses, and male mating in both wild-type and daf-2(e1370) worms.
Serotonin receptors antagonistically modulate Caenorhabditis elegans longevity
This study investigates a variety of mutations in serotonin‐signal genes, including serotonin biosynthesis genes, a serotonin transporter gene, and serotonin receptor genes, and suggests that serotonin signal antagonistically modulates longevity through different serotonin receptors.
Bilobalide modulates serotonin-controlled behaviors in the nematode Caenorhabditis elegans
Results suggest that bilobalide may modulate specific 5-HT receptor subtypes, which involves interplay with dopamine transmission, and additional studies for the function of bilobalides in neurotransmitter systems could aid in the understanding of its neuroprotective properties.
EGF signaling comes of age: Promotion of healthy aging in C. elegans
Increased whole cerebellar serotonin in aged C57BL/6 mice.
Examining total cerebellar glutamate, glutamine, GABA, glycine, dopamine, norepinephrine, tryptophan, serotonin, alanine, threonine, and asparagine content from male 2-3-month and 21-24-month-old mice found a significant increase in cerebellary serotonin in aged versus young mice, but otherwise no significant phenotypic differences in measured neurotransmitter concentrations.
Serotonin: from top to bottom
It is demonstrated that serotonin is potentially involved in whole organism aging through its links with multiple organs, the immune system and microRNAs and methods to investigate these links are discussed.
New haystacks reveal new needles: using Caenorhabditis elegans to identify novel targets for ameliorating body composition changes during human aging.
  • C. Wolkow
  • Biology
    Interdisciplinary topics in gerontology
  • 2010
A deeper understanding is developed of the ways that C.elegans can be used for mechanistic gerontological studies and how these pathways might provide useful therapeutic approaches for combating muscle loss during aging.
Novel EGF pathway regulators modulate C. elegans healthspan and lifespan via EGF receptor, PLC‐γ, and IP3R activation
HPA‐1 and HPA‐2 are identified as novel negative regulators of EGF signaling and constitutes the first report of E GF signaling as a major pathway for healthy aging, raising the possibility that EGF family members should be investigated for similar activities in higher organisms.


Behavioral deficits during early stages of aging in Caenorhabditis elegans result from locomotory deficits possibly linked to muscle frailty.
Treatment with a muscarinic agonist significantly improved locomotory behavior in aged animals, indicating that improved neuromuscular signaling may be one strategy for reducing the severity of age-related behavioral impairments.
Feeding status and serotonin rapidly and reversibly modulate a Caenorhabditis elegans chemosensory circuit.
It is shown that both food and 5-HT signaling modulate chemosensory avoidance response of octanol in C. elegans, and that this modulation is both rapid and reversible.
Mutations in the Caenorhabditis elegans Serotonin Reuptake Transporter MOD-5 Reveal Serotonin-Dependent and -Independent Activities of Fluoxetine
Analysis of the MOD-5-independent behavioral effects of fluoxetine could lead to the identification of novel targets of fluxetine and could facilitate the development of more specific human pharmaceuticals.
Food and metabolic signalling defects in a Caenorhabditis elegans serotonin-synthesis mutant
Analysis of the C. elegans genome sequence showed that there is a single tryptophan hydroxylase gene (tph-1)—the key enzyme for serotonin biosynthesis—which is similar to mammalian serotonergic input to metabolism and obesity.
Measurements of age-related changes of physiological processes that predict lifespan of Caenorhabditis elegans.
These findings suggest that the declines of pharyngeal pumping and body movement cause a decline in survival probability or that a shared regulatory system mediates the declines in pharynGEal pumping, body movement, and survival probability.
Aging-Dependent and -Independent Modulation of Associative Learning Behavior by Insulin/Insulin-Like Growth Factor-1 Signal in Caenorhabditis elegans
Roles of the Age mutations in modulation of certain behavioral plasticity are highlighted, including mutations in the daf-7 TGFβ gene, which functions in parallel to the insulin/IGF-1 pathway, caused deficits in acquisition of temperature-food and temperature-starvation association.
Serotonin regulates repolarization of the C. elegans pharyngeal muscle
Reciprocal regulation of pharyngeal behavior by serotonin and octopamine provides a mechanism for adapting to the presence and absence of food, respectively.
Serotonin-deficient mutants and male mating behavior in the nematode Caenorhabditis elegans
  • CM Loer, C. Kenyon
  • Biology, Psychology
    The Journal of neuroscience : the official journal of the Society for Neuroscience
  • 1993
The turning defect of cat-4 males was rescued by exogenous serotonin, consistent with the idea that their behavioral defect is caused by a lack of serotonin, and three serotonin-deficient mutants the authors analyzed shared certain behavioral traits.