Manipulation of serotonin signal suppresses early phase of behavioral aging in Caenorhabditis elegans 

@article{Murakami2008ManipulationOS,
  title={Manipulation of serotonin signal suppresses early phase of behavioral aging in Caenorhabditis elegans
},
  author={Hana Murakami and Karalee Bessinger and Jason Hellmann and Shin Murakami},
  journal={Neurobiology of Aging},
  year={2008},
  volume={29},
  pages={1093-1100}
}
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34 Citations
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Longevity Manipulations Differentially Affect Serotonin/Dopamine Level and Behavioral Deterioration in Aging Caenorhabditis elegans
TLDR
It is reported that serotonin (5-HT) and dopamine (DA) level decrease with age in C. elegans, and it is found that elevating 5-HT/DA ameliorates age-related deterioration of pharyngeal pumping, food-induced slowing responses, and male mating in both wild-type and daf-2(e1370) worms.
Behavioral decay in aging male C. elegans correlates with increased cell excitability
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This study investigates a variety of mutations in serotonin‐signal genes, including serotonin biosynthesis genes, a serotonin transporter gene, and serotonin receptor genes, and suggests that serotonin signal antagonistically modulates longevity through different serotonin receptors.
Chapter 12 – Age-Dependent Modulation of Learning and Memory in Caenorhabditis elegans
Bilobalide modulates serotonin-controlled behaviors in the nematode Caenorhabditis elegans
TLDR
Results suggest that bilobalide may modulate specific 5-HT receptor subtypes, which involves interplay with dopamine transmission, and additional studies for the function of bilobalides in neurotransmitter systems could aid in the understanding of its neuroprotective properties.
EGF signaling comes of age: Promotion of healthy aging in C. elegans
Increased whole cerebellar serotonin in aged C57BL/6 mice.
TLDR
Examining total cerebellar glutamate, glutamine, GABA, glycine, dopamine, norepinephrine, tryptophan, serotonin, alanine, threonine, and asparagine content from male 2-3-month and 21-24-month-old mice found a significant increase in cerebellary serotonin in aged versus young mice, but otherwise no significant phenotypic differences in measured neurotransmitter concentrations.
Serotonin: from top to bottom
TLDR
It is demonstrated that serotonin is potentially involved in whole organism aging through its links with multiple organs, the immune system and microRNAs and methods to investigate these links are discussed.
New haystacks reveal new needles: using Caenorhabditis elegans to identify novel targets for ameliorating body composition changes during human aging.
  • C. Wolkow
  • Biology
    Interdisciplinary topics in gerontology
  • 2010
TLDR
A deeper understanding is developed of the ways that C.elegans can be used for mechanistic gerontological studies and how these pathways might provide useful therapeutic approaches for combating muscle loss during aging.
Novel EGF pathway regulators modulate C. elegans healthspan and lifespan via EGF receptor, PLC‐γ, and IP3R activation
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HPA‐1 and HPA‐2 are identified as novel negative regulators of EGF signaling and constitutes the first report of E GF signaling as a major pathway for healthy aging, raising the possibility that EGF family members should be investigated for similar activities in higher organisms.
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