Manipulation of serotonin signal suppresses early phase of behavioral aging in Caenorhabditis elegans
@article{Murakami2008ManipulationOS, title={Manipulation of serotonin signal suppresses early phase of behavioral aging in Caenorhabditis elegans }, author={Hana Murakami and Karalee Bessinger and Jason Hellmann and Shin Murakami}, journal={Neurobiology of Aging}, year={2008}, volume={29}, pages={1093-1100} }
33 Citations
Longevity Manipulations Differentially Affect Serotonin/Dopamine Level and Behavioral Deterioration in Aging Caenorhabditis elegans
- BiologyThe Journal of Neuroscience
- 2014
It is reported that serotonin (5-HT) and dopamine (DA) level decrease with age in C. elegans, and it is found that elevating 5-HT/DA ameliorates age-related deterioration of pharyngeal pumping, food-induced slowing responses, and male mating in both wild-type and daf-2(e1370) worms.
Behavioral decay in aging male C. elegans correlates with increased cell excitability
- BiologyNeurobiology of Aging
- 2012
Serotonin receptors antagonistically modulate Caenorhabditis elegans longevity
- BiologyAging cell
- 2007
This study investigates a variety of mutations in serotonin‐signal genes, including serotonin biosynthesis genes, a serotonin transporter gene, and serotonin receptor genes, and suggests that serotonin signal antagonistically modulates longevity through different serotonin receptors.
Chapter 12 – Age-Dependent Modulation of Learning and Memory in Caenorhabditis elegans
- Biology, Psychology
- 2013
Bilobalide modulates serotonin-controlled behaviors in the nematode Caenorhabditis elegans
- Biology, PsychologyBMC Neuroscience
- 2008
Results suggest that bilobalide may modulate specific 5-HT receptor subtypes, which involves interplay with dopamine transmission, and additional studies for the function of bilobalides in neurotransmitter systems could aid in the understanding of its neuroprotective properties.
EGF signaling comes of age: Promotion of healthy aging in C. elegans
- BiologyExperimental Gerontology
- 2011
Increased whole cerebellar serotonin in aged C57BL/6 mice.
- Biology, PsychologyMatters
- 2017
Examining total cerebellar glutamate, glutamine, GABA, glycine, dopamine, norepinephrine, tryptophan, serotonin, alanine, threonine, and asparagine content from male 2-3-month and 21-24-month-old mice found a significant increase in cerebellary serotonin in aged versus young mice, but otherwise no significant phenotypic differences in measured neurotransmitter concentrations.
Serotonin: from top to bottom
- Biology, PsychologyBiogerontology
- 2012
It is demonstrated that serotonin is potentially involved in whole organism aging through its links with multiple organs, the immune system and microRNAs and methods to investigate these links are discussed.
New haystacks reveal new needles: using Caenorhabditis elegans to identify novel targets for ameliorating body composition changes during human aging.
- BiologyInterdisciplinary topics in gerontology
- 2010
A deeper understanding is developed of the ways that C.elegans can be used for mechanistic gerontological studies and how these pathways might provide useful therapeutic approaches for combating muscle loss during aging.
Novel EGF pathway regulators modulate C. elegans healthspan and lifespan via EGF receptor, PLC‐γ, and IP3R activation
- Biology, MedicineAging cell
- 2010
HPA‐1 and HPA‐2 are identified as novel negative regulators of EGF signaling and constitutes the first report of E GF signaling as a major pathway for healthy aging, raising the possibility that EGF family members should be investigated for similar activities in higher organisms.
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