Manipulation of serotonin signal suppresses early phase of behavioral aging in Caenorhabditis elegans

  title={Manipulation of serotonin signal suppresses early phase of behavioral aging in Caenorhabditis elegans},
  author={Hana Murakami and Karalee Bessinger and J. Hellmann and S. Murakami},
  journal={Neurobiology of Aging},
  • Hana Murakami, Karalee Bessinger, +1 author S. Murakami
  • Published 2008
  • Biology, Medicine
  • Neurobiology of Aging
  • Aging is associated with progressive changes in behavioral functions, in part caused by muscle frailty, called sarcopenia. However, it was not clear whether certain neurotransmitters are directly involved in behavioral aging. Here we investigated aging of locomotion behaviors with an associative learning property, called basal and enhanced slowing response in Caenorhabditis elegans. Basal slowing response is a modest slowdown in response to food, while enhanced slowing response is a greater… CONTINUE READING
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