Manipulation of protein kinases reveals different mechanisms for upregulation of heat shock proteins in motor neurons and non-neuronal cells

@article{Taylor2007ManipulationOP,
  title={Manipulation of protein kinases reveals different mechanisms for upregulation of heat shock proteins in motor neurons and non-neuronal cells},
  author={David C. M. Taylor and Paul De Koninck and Sandra Minotti and Heather D. Durham},
  journal={Molecular and Cellular Neuroscience},
  year={2007},
  volume={34},
  pages={20-33}
}
Motor neurons have a high threshold for induction of heat shock proteins (Hsps) in response to stress, a property associated with impaired ability to activate heat shock transcription factor 1 (Hsf1). Hyperphosphorylation of Hsf1 has been established as a requirement for transactivation of heat shock genes. This study demonstrated that the impaired heat shock response in motor neurons is not due to altered phosphorylation of Hsf1 by kinases previously shown to affect activation of Hsf1 in other… CONTINUE READING
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