Manipulation of N,O-nucleophilicity: efficient formation of 4-N-substituted 2,4-dihydro-3H-1,2,4-triazolin-3-ones.


A new efficient two-step synthesis of 2,4-dihydro-3H-1,2,4-triazolin-3-ones (triazolinones) from readily available amines is reported. Our novel conditions using hexamethyl disilazane, bromotrimethylsilane, and a catalytic amount of ammonium sulfate smoothly cyclize 1-formyl and 1-acetyl semicarbazides to the target triazolinones. This transformation… (More)


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