Manipulating the in vivo immune response by targeted gene knockdown.

  title={Manipulating the in vivo immune response by targeted gene knockdown.},
  author={Judy Lieberman},
  journal={Current opinion in immunology},
Aptamers, nucleic acids selected for high affinity binding to proteins, can be used to activate or antagonize immune mediators or receptors in a location and cell-type specific manner and to enhance antigen presentation. They can also be linked to other molecules (other aptamers, siRNAs or miRNAs, proteins, toxins) to produce multifunctional compounds for targeted immune modulation in vivo. Aptamer-siRNA chimeras (AsiCs) that induce efficient cell-specific knockdown in immune cells in vitro and… CONTINUE READING