Manipulating the extracellular matrix and its role in brain and spinal cord plasticity and repair.

@article{Burnside2014ManipulatingTE,
  title={Manipulating the extracellular matrix and its role in brain and spinal cord plasticity and repair.},
  author={Emily R Burnside and Elizabeth J. Bradbury},
  journal={Neuropathology and applied neurobiology},
  year={2014},
  volume={40 1},
  pages={26-59}
}
Brain and spinal cord injury can result in permanent cognitive, motor, sensory and autonomic deficits. The central nervous system (CNS) has a poor intrinsic capacity for regeneration, although some functional recovery does occur. This is mainly in the form of sprouting, dendritic remodelling and changes in neuronal coding, firing and synaptic properties; elements collectively known as plasticity. An important approach to repair the injured CNS is therefore to harness, promote and refine… CONTINUE READING

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