Manipulating the PD-1 pathway to improve immunity.

  title={Manipulating the PD-1 pathway to improve immunity.},
  author={Alice O Kamphorst and Rafi Ahmed},
  journal={Current opinion in immunology},
  volume={25 3},
PD-1 is an inhibitory receptor induced in T cells by antigen stimulation and sustained PD-1 expression plays a key role in T cell dysfunction. Blocking PD-1 signaling rescues exhausted T cells and is an effective treatment for chronic infections and cancer. Nonetheless, combining PD-1 pathway blockade to therapeutic vaccination should further improve T cell rescue. PD-1 is induced shortly after T cell priming, but little is known about the role of PD-1 in the initiation of immune responses. In… CONTINUE READING