Manipulating redox and ATP balancing for improved production of succinate in E. coli.

@article{Singh2011ManipulatingRA,
  title={Manipulating redox and ATP balancing for improved production of succinate in E. coli.},
  author={Amarjeet Singh and Keng Cher Soh and Vassily Hatzimanikatis and Ryan T. Gill},
  journal={Metabolic engineering},
  year={2011},
  volume={13 1},
  pages={76-81}
}
Redox and energy balance plays a key role in determining microbial fitness. Efforts to redirect bacterial metabolism often involve overexpression and deletion of genes surrounding key central metabolites, such as pyruvate and acetyl-coA. In the case of metabolic engineering of Escherichia coli for succinate production, efforts have mainly focused on the manipulation of key pyruvate metabolizing enzymes. E. coli AFP111 strain lacking ldhA, pflB and ptsG encoded activities accumulates acetate and… CONTINUE READING

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