Manipulating mammalian genome by gene targeting.

@article{Volarevi1999ManipulatingMG,
  title={Manipulating mammalian genome by gene targeting.},
  author={Sini{\vs}a Volarevi{\'c} and Mario Pende and Nicholas John Pullen},
  journal={Croatian medical journal},
  year={1999},
  volume={40 3},
  pages={
          368-74
        }
}
The development of strategies which allow the inactivation of specific murine genes by homologous recombination in embryonic cells has revolutionized biological science in the last 10 years. A large number of mice carrying genetic lesions, generated by gene targeting technology, has tremendously increased our knowledge in many areas of biology, culminating in the identification of mouse models for human genetic disorders. These findings have been recently complemented by "conditional" gene… CONTINUE READING

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