Manipulating Kv4.2 identifies a specific component of hippocampal pyramidal neuron A-current that depends upon Kv4.2 expression.

@article{Lauver2006ManipulatingKI,
  title={Manipulating Kv4.2 identifies a specific component of hippocampal pyramidal neuron A-current that depends upon Kv4.2 expression.},
  author={Aaron D. Lauver and Li-Lian Yuan and Andreas Jeromin and Brian M. Nadin and Jos{\'e} J. Santana Rodr{\'i}guez and Heather A. Davies and Michael G. Stewart and G Wu and Paul J. Pfaffinger},
  journal={Journal of neurochemistry},
  year={2006},
  volume={99 4},
  pages={1207-23}
}
The somatodendritic A-current, I(SA), in hippocampal CA1 pyramidal neurons regulates the processing of synaptic inputs and the amplitude of back propagating action potentials into the dendritic tree, as well as the action potential firing properties at the soma. In this study, we have used RNA interference and over-expression to show that expression of the Kv4.2 gene specifically regulates the I(SA) component of A-current in these neurons. In dissociated hippocampal pyramidal neuron cultures… CONTINUE READING

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