Manifold Learning for Human Population Structure Studies

@inproceedings{Siu2012ManifoldLF,
  title={Manifold Learning for Human Population Structure Studies},
  author={Hoicheong Siu and Li Jin and Momiao Xiong},
  booktitle={PloS one},
  year={2012}
}
The dimension of the population genetics data produced by next-generation sequencing platforms is extremely high. However, the "intrinsic dimensionality" of sequence data, which determines the structure of populations, is much lower. This motivates us to use locally linear embedding (LLE) which projects high dimensional genomic data into low dimensional, neighborhood preserving embedding, as a general framework for population structure and historical inference. To facilitate application of the… CONTINUE READING

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