Manifestation of the limb prepattern: limb development in the absence of sonic hedgehog function.

@article{Chiang2001ManifestationOT,
  title={Manifestation of the limb prepattern: limb development in the absence of sonic hedgehog function.},
  author={C W Chiang and Ying Litingtung and Matthew P. Harris and B K Simandl and Y Li and Philip A Beachy and John F. Fallon},
  journal={Developmental biology},
  year={2001},
  volume={236 2},
  pages={421-35}
}
The secreted protein encoded by the Sonic hedgehog (Shh) gene is localized to the posterior margin of vertebrate limb buds and is thought to be a key signal in establishing anterior-posterior limb polarity. In the Shh(-/-) mutant mouse, the development of many embryonic structures, including the limb, is severely compromised. In this study, we report the analysis of Shh(-/-) mutant limbs in detail. Each mutant embryo has four limbs with recognizable humerus/femur bones that have anterior… CONTINUE READING
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WNT signals Copyright © 2001 by Academic Press . All right control FGF - dependent limb initiation and AER induction in the chick embryo

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