Manic switches induced by antidepressants: an umbrella review comparing randomized controlled trials and observational studies.

Abstract

OBJECTIVE We aimed to explore whether the prevalence of manic switch was underestimated in randomized controlled trials (RCTs) compared to observational studies (OSs). METHOD Meta-analyses and simple and systematic reviews were identified by two reviewers in a blinded, standardized manner. All relevant references were extracted to include RCTs and OSs… (More)
DOI: 10.1111/acps.12672

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