Mangostanaxanthones III and IV: advanced glycation end-product inhibitors from the pericarp of Garcinia mangostana

@article{Abdallah2016MangostanaxanthonesIA,
  title={Mangostanaxanthones III and IV: advanced glycation end-product inhibitors from the pericarp of Garcinia mangostana},
  author={Hossam Mohamed Abdallah and Hany M El-Bassossy and Gamal A. Mohamed and Ali M. El-Halawany and Khalid Z. Alshali and Zainy Mohammed Banjar},
  journal={Journal of Natural Medicines},
  year={2016},
  volume={71},
  pages={216-226}
}
Advanced glycation end-products (AGEs) are associated with a non-enzymatic reaction between the amino group of a protein and the carbonyl group of a sugar during hyperglycemia. The precipitation of AGEs in different tissues leads to many complications, such as endothelial dysfunction, cardiovascular complications, atherosclerosis, retinopathy, neuropathy, and Alzheimer’s disease. Garcinia mangostana L. (Clusiaceae) (GM) was selected owing to the ability of its polar and non-polar fractions to… 
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TLDR
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Mangostanaxanthone IV (MX-IV) is deemed as a prosperous nominee for AD management with obvious neuro-protective effects that were comparable to the standard drug donepezil.
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