Magnetic resonance imaging studies in bipolar disorder and schizophrenia: meta-analysis
- A. Danilo, J. Cavanagh, D. Gerber, S. M. Lawrie, A.M.K.P. Ebmeier
- Br J Psychiatry
Bipolar disorder is a mental illness where changes in brain functions transform normal emotions/sentiments to dramatic mood swing between mania and depression. Severity in mood swing may lead to impair normal functioning at work, at school and in relationships etc. The common interventions for management for bipolar disorder include medication, psychotherapy and electroconvulsive therapy (ECT) as per need of patient. This observational study was carried out on 40 patients diagnosed with bipolar disorder at Punjab Institute of Mental Health (PIMH), Lahore. The main aims included, evaluation of the rationality of prescribing/use of medicines and patient – health care provider’s interaction. The results indicated that three mood stabilizers, namely, Sodium Valproate (55% patients), Carbamazepine (27.50%patients), Lithium (5% patients) and combination of two mood stabilizer (5% patients) were prescribed /used. The combination of the antipsychotic, mood stabilizer and benzodiazepines was the main treatment regimen of bipolar disorder (85% Patients) in PIMH. Non-compliance/adherence was the vital issue in about 62.5% patient. 67.5% relapse was a big issue in BD at PIMH. The effective patient – health care provider’s interaction was practically non-existent. Neither pharmaceutical care practiced nor the pharmacists were involved in drug use process. PIMH, Lahore is a blessing for poor people of Pakistan, but authorities need to rationalize management of BD for best interest of patient as well as society.