Manganoporphyrins increase ascorbate-induced cytotoxicity by enhancing H2O2 generation.

  title={Manganoporphyrins increase ascorbate-induced cytotoxicity by enhancing H2O2 generation.},
  author={Malvika Rawal and Samuel R Schroeder and Brett A Wagner and Cameron M Cushing and Jessemae L Welsh and Anna M. Button and Juan Du and Zita A. Sibenaller and Garry R Buettner and Joseph J. Cullen},
  journal={Cancer research},
  volume={73 16},
Renewed interest in using pharmacological ascorbate (AscH-) to treat cancer has prompted interest in leveraging its cytotoxic mechanism of action. A central feature of AscH- action in cancer cells is its ability to act as an electron donor to O2 for generating H2O2. We hypothesized that catalytic manganoporphyrins (MnP) would increase AscH- oxidation rates, thereby increasing H2O2 fluxes and cytotoxicity. Three different MnPs were tested (MnTBAP, MnT2EPyP, and MnT4MPyP), exhibiting a range of… CONTINUE READING


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Ascorbic acid free radicals. I. Pulse radiolysis study of optical absorption and kinetic properties

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  • J Am Chem Soc 1971;93:5624–29
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