Manganic porphyrins possess catalase activity and protect endothelial cells against hydrogen peroxide-mediated injury.

@article{Day1997ManganicPP,
  title={Manganic porphyrins possess catalase activity and protect endothelial cells against hydrogen peroxide-mediated injury.},
  author={Brian J. Day and Irwin Fridovich and James D. Crapo},
  journal={Archives of biochemistry and biophysics},
  year={1997},
  volume={347 2},
  pages={256-62}
}
Manganic porphyrins are redox active metal complexes that have been employed as superoxide dismutase mimics. We tested whether these metalloporphyrins could also dismute hydrogen peroxide (H2O2) and whether they could protect endothelial cells against H2O2. Both of the manganic metalloporphyrins tested were found to catalytically dismute H2O2. These manganic porphyrins also protected endothelial cells in dose-dependent manners against H2O2-mediated injury with MnTMPyP having an EC50 of 8 microM… CONTINUE READING