Manganese transport in the rat optic nerve evaluated with spatial- and time-resolved magnetic resonance imaging.

@article{Olsen2010ManganeseTI,
  title={Manganese transport in the rat optic nerve evaluated with spatial- and time-resolved magnetic resonance imaging.},
  author={\Oystein Olsen and Anders Kristoffersen and Marte Thuen and Axel Sandvig and Christian Brekken and Olav Haraldseth and P{\aa}l Erik Goa},
  journal={Journal of magnetic resonance imaging : JMRI},
  year={2010},
  volume={32 3},
  pages={551-60}
}
PURPOSE 1) To evaluate a novel theoretical model for in vivo axonal Mn(2+) transport with MRI data from the rat optic nerve (ON); and 2) to compare predictions from the new model with previously reported experimental data. MATERIALS AND METHODS Time-resolved in vivo T(1)-weighted magnetic resonance imaging (MRI) of adult female Sprague-Dawley rat (n = 9) ON was obtained at different timepoints after intravitreal MnCl(2) injection. A concentration-dependent and a rate-dependent function for… CONTINUE READING

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