Manganese toxicokinetics at the blood-brain barrier.

  title={Manganese toxicokinetics at the blood-brain barrier.},
  author={Robert A. Yokel and Janelle S Crossgrove},
  journal={Research report},
  pages={7-58; discussion 59-73}
Increased manganese (Mn) use in manufacturing and in gasoline has raised concern about Mn-induced parkinsonism. Previous research indicated carrier-mediated brain entry but did not assess brain efflux. Using in situ rat brain perfusion, we studied influx across the blood-brain barrier (BBB*) of three predominant plasma Mn species available to enter the brain: Mn2+, Mn citrate, and Mn transferrin. Our results suggested transporter-mediated uptake of these species. The uptake rate was greatest… CONTINUE READING


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