Manganese superoxide dismutase suppresses hypoxic induction of hypoxia-inducible factor-1α and vascular endothelial growth factor

@article{Wang2005ManganeseSD,
  title={Manganese superoxide dismutase suppresses hypoxic induction of hypoxia-inducible factor-1α and vascular endothelial growth factor},
  author={Min Wang and Jeanie S Kirk and Sujatha L Venkataraman and F E Domann and Hannah J. Zhang and Freya Q. Schafer and Shawn W. Flanagan and Christine Darby Weydert and Douglas R. Spitz and Garry R Buettner and Larry W. Oberley},
  journal={Oncogene},
  year={2005},
  volume={24},
  pages={8154-8166}
}
Hypoxia-inducible factor-1 (HIF-1) is a transcription factor that governs cellular responses to reduced O2 availability by mediating crucial homeostatic processes. HIF-1 is composed of an HIF-1α subunit and an HIF-1β subunit. HIF-1α is degraded following enzyme-dependent hydroxylation of prolines of HIF-1α in the presence of molecular oxygen, Fe2+, α-ketoglutarate, and ascorbate. These cofactors contribute to the redox environment of cells. The antioxidant enzyme manganese superoxide dismutase… CONTINUE READING
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