Manganese superoxide dismutase protects the proliferative capacity of confluent normal human fibroblasts.

@article{Sarsour2005ManganeseSD,
  title={Manganese superoxide dismutase protects the proliferative capacity of confluent normal human fibroblasts.},
  author={Ehab H. Sarsour and Manjula Agarwal and Tej K Pandita and Larry W. Oberley and Prabhat C. Goswami},
  journal={The Journal of biological chemistry},
  year={2005},
  volume={280 18},
  pages={18033-41}
}
We tested the hypothesis that manganese superoxide dismutase (MnSOD), an antioxidant enzyme, regulates the proliferative potential of confluent human fibroblasts. Normal human skin (AG01522) and lung (WI38, CCL-75) fibroblasts kept in confluence (>95% G(0)/G(1)) showed a significant decrease in their capacity to re-enter the proliferation cycle after 40-60… CONTINUE READING