Manganese superoxide dismutase promotes anoikis resistance and tumor metastasis

  title={Manganese superoxide dismutase promotes anoikis resistance and tumor metastasis},
  author={Sushama Kamarajugadda and Qingsong Cai and Huan Chen and Sushrusha Nayak and Jing Z. Zhu and Mingyuan He and Ying Jin and Yanling Zhang and Lingbao Ai and Seth S. Martin and Marcus C. B. Tan and Jianrong Lu},
  booktitle={Cell Death and Disease},
Normal cells require adhesion to extracellular matrix for survival. Cell detachment causes a drastic increase in reactive oxygen species (ROS) that promotes anoikis. In the present study, we observed that upon detachment from matrix, human mammary epithelial cells strongly upregulate manganese superoxide dismutase (MnSOD, or SOD2), a principal mitochondrial antioxidant enzyme that detoxifies ROS through dismutation of superoxide. Induction of MnSOD by cell detachment is dependent on the NFκB… CONTINUE READING
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