Manganese superoxide dismutase induces migration and invasion of tongue squamous cell carcinoma via H2O2-dependent Snail signaling.

@article{Liu2012ManganeseSD,
  title={Manganese superoxide dismutase induces migration and invasion of tongue squamous cell carcinoma via H2O2-dependent Snail signaling.},
  author={Zhonghua Liu and Su Li and Yuchen Cai and Anxun Wang and Qianting He and Chaoxu Zheng and Tingting Zhao and Xueqiang Ding and Xiaofeng Zhou},
  journal={Free radical biology & medicine},
  year={2012},
  volume={53 1},
  pages={
          44-50
        }
}
Our previous studies had revealed that the dysregulation of manganese superoxide dismutase (SOD2) expression was a frequent event in tongue squamous cell carcinoma (TSCC) and may be associated with enhanced metastatic potential. To further evaluate the mechanism of SOD2-mediated metastasis in TSCC, TSCC cell lines with different metastatic potentials (i.e., the highly metastatic UM1 line and the UM2 line, which displays fewer metastases) were used. Compared to UM2 cells, UM1 cells exhibited… CONTINUE READING
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