Manganese superoxide dismutase gene therapy protects against irradiation-induced cystitis.

  title={Manganese superoxide dismutase gene therapy protects against irradiation-induced cystitis.},
  author={Anthony J Kanai and Mark Lawrence Zeidel and John P. Lavelle and Joel S. Greenberger and Lori Ann Birder and William Chet de Groat and Gerard L Apodaca and Susan A Meyers and Richard Ramage and Michael Wayne Epperly},
  journal={American journal of physiology. Renal physiology},
  volume={283 6},
Urinary bladder cystitis occurs in patients receiving radiation therapy for pelvic tumors. Radiation-induced formation of superoxide radicals is believed to damage the urothelium, exposing the underlying bladder smooth muscle to urine, culminating in nerve irritation and muscle dysfunction. We tested whether overexpression of MnSOD could decrease superoxide levels and protect the bladder from radiation damage. Pelvic irradiation led to sloughing of urothelial umbrella cells, with decreased… CONTINUE READING
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Bladder permeability barrier: F1311 MNSOD PROTECTS AGAINST RADIATION CYSTITIS AJP-Renal Physiol

  • JP Lavelle, SA Meyers, +4 authors ML. Zeidel
  • Jne 29,
  • 2002
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