Manganese superoxide dismutase (SOD2/MnSOD)/catalase and SOD2/GPx1 ratios as biomarkers for tumor progression and metastasis in prostate, colon, and lung cancer.

@article{Miar2015ManganeseSD,
  title={Manganese superoxide dismutase (SOD2/MnSOD)/catalase and SOD2/GPx1 ratios as biomarkers for tumor progression and metastasis in prostate, colon, and lung cancer.},
  author={Ana Miar and David Hevia and Henar Mu{\~n}oz-Cimadevilla and Aurora Astudillo and Julio Velasco and Rosa M S{\'a}inz and Juan C Mayo},
  journal={Free radical biology & medicine},
  year={2015},
  volume={85},
  pages={45-55}
}
The role of manganese-dependent superoxide dismutase (SOD2/MnSOD) during tumor progression has been studied for several decades with controversial results. While SOD2 downregulation was initially associated with tumor initiation and was proposed as a tumor suppressor gene, recent studies have reported that SOD2 might favor tumor progression and dissemination. To our knowledge this is the first time that changes in SOD2 expression in three different types of tumors, i.e., prostate, lung, and… CONTINUE READING
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