Manganese superoxide dismutase (MnSOD) polymorphism, α-tocopherol supplementation and prostate cancer risk in the Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study (Finland)

@article{Woodson2003ManganeseSD,
  title={Manganese superoxide dismutase (MnSOD) polymorphism, α-tocopherol supplementation and prostate cancer risk in the Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study (Finland)},
  author={Karen Woodson and Joseph A. Tangrea and Teresa A. Lehman and Ramakrishna V Modali and Kristin M. Taylor and K. F. Snyder and Philip R. Taylor and Jarmo R Virtamo and Demetrius Albanes},
  journal={Cancer Causes & Control},
  year={2003},
  volume={14},
  pages={513-518}
}
Objective: Manganese superoxide dismutase (MnSOD) is a mitochondrial enzyme that plays a key role in protecting the cell from oxidative damage. A polymorphism in the mitochondrial targeting sequence (a valine to alanine substitution), thought to alter transport of the enzyme into mitochondria, has been associated with increased risk for breast cancer with a more pronounced association among women with low intake of dietary antioxidants. We examined the role of MnSOD in the development of… CONTINUE READING