Manganese-mediated up-regulation of HIF-1alpha protein in Hep2 human laryngeal epithelial cells via activation of the family of MAPKs.

@article{Shin2010ManganesemediatedUO,
  title={Manganese-mediated up-regulation of HIF-1alpha protein in Hep2 human laryngeal epithelial cells via activation of the family of MAPKs.},
  author={Hee-Jung Shin and Mi-Sun Choi and Nam-Hee Ryoo and Ki-Young Nam and Gy-Young Park and Jae-Hoon Bae and Seong-il Suh and Won-Ki Baek and Jong-Wook Park and Byeong-Churl Jang},
  journal={Toxicology in vitro : an international journal published in association with BIBRA},
  year={2010},
  volume={24 4},
  pages={1208-14}
}
High exposure of manganese is believed to be a risk factor for respiratory diseases. Evidence suggests that overexpression of HIF-1alpha transcription factor is linked to pulmonary inflammation and vascular change. In this study, we investigated the effect of manganese-chloride (manganese) on expression and activity of HIF-1alpha in various human airway cells, including Hep2 (laryngeal), H292 (bronchial), and A549 (lung). Profoundly, while manganese treatment led to low or little effect on… CONTINUE READING
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