Manganese kinetics demonstrated double contrast in acute but not in chronic infarction in a mouse model of myocardial occlusion reperfusion.

@article{Delattre2012ManganeseKD,
  title={Manganese kinetics demonstrated double contrast in acute but not in chronic infarction in a mouse model of myocardial occlusion reperfusion.},
  author={B{\'e}n{\'e}dicte M. A. Delattre and Vincent Braunersreuther and St{\'e}phany Gardier and Jean-No{\"e}l Hyacinthe and Lindsey Alexandra Crowe and François Mach and Jean-Paul Vall{\'e}e},
  journal={NMR in biomedicine},
  year={2012},
  volume={25 4},
  pages={489-97}
}
Manganese (Mn(2+)) is considered as a specific MRI contrast agent that enters viable cardiomyocytes through calcium pathways. Compared to extracellular gadolinium based contrast agents, it has the potential to assess cell viability. To date, only information from the washout phase after recirculation has been used for the detection and characterization of myocardial infarct. This study showed for the first time that in a mouse model of coronary occlusion-reperfusion, Mn(2+) wash-in kinetics are… CONTINUE READING