Manganese ion enhances T1‐weighted MRI during brain activation: An approach to direct imaging of brain function

  title={Manganese ion enhances T1‐weighted MRI during brain activation: An approach to direct imaging of brain function},
  author={Yi-jen Lin and Alan P. Koretsky},
  journal={Magnetic Resonance in Medicine},
Present techniques for functional MRI rely on detecting changes in hemodynamics that result as a consequence of brain activation. It would be useful if MRI techniques could be developed that enable imaging of a parameter directly related to neuronal activity. Influx of calcium into neurons is necessary for release of neurotransmitters. Divalent manganese ions (Mn2+) can enter cells through voltage‐gated calcium channels and Mn2+ is paramagnetic. Mn2+ accumulation in brain due to activation… 

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