Manganese induces the mitochondrial permeability transition in cultured astrocytes.

  title={Manganese induces the mitochondrial permeability transition in cultured astrocytes.},
  author={Kakulavarapu V. Rama Rao and M D Norenberg},
  journal={The Journal of biological chemistry},
  volume={279 31},
Manganese is known to cause central nervous system injury leading to parkinsonism and to contribute to the pathogenesis of hepatic encephalopathy. Although mechanisms of manganese neurotoxicity are not completely understood, chronic exposure of various cell types to manganese has shown oxidative stress and mitochondrial energy failure, factors that are often implicated in the induction of the mitochondrial permeability transition (MPT). In this study, we examined whether exposure of cultured… CONTINUE READING
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