Manganese induces neurite outgrowth in PC12 cells via upregulation of alpha(v) integrins.

@article{Lein2000ManganeseIN,
  title={Manganese induces neurite outgrowth in PC12 cells via upregulation of alpha(v) integrins.},
  author={Pamela J Lein and Patrick J. Gallagher and Jeffrey Amodeo and Heather L. Howie and Jerome A. Roth},
  journal={Brain research},
  year={2000},
  volume={885 2},
  pages={
          220-30
        }
}
Previous studies have demonstrated that the divalent cation manganese (Mn) causes PC12 cells to form neurites in the absence of NGF. Since divalent cations modulate the binding affinity and specificity of integrins, and integrin function affects neurite outgrowth, we tested the hypothesis that Mn induces neurite outgrowth through an integrin-dependent signaling pathway. Our studies support this hypothesis. Function-blocking antisera specific for beta(1) integrins block the neurite-promoting… CONTINUE READING
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