Manganese fluxes and manganese-dependent neurotransmitter release in presynaptic nerve endings isolated from rat brain.

@article{Drapeau1984ManganeseFA,
  title={Manganese fluxes and manganese-dependent neurotransmitter release in presynaptic nerve endings isolated from rat brain.},
  author={P Drapeau and D. A. Nachshen},
  journal={The Journal of physiology},
  year={1984},
  volume={348},
  pages={493-510}
}
The uptake and efflux of 54Mn and 45Ca, and the release of dopamine (DA) were measured in pinched-off presynaptic nerve endings (synaptosomes) isolated from rat brain. The uptake of Mn and Ca was increased when forebrain or striatal synaptosomes were incubated in a depolarizing, K-rich solution. The time courses of K-stimulated Mn and Ca entry were similar: there was initially a high rate of ion accumulation, lasting 1-3 s, that gradually levelled off. The initial uptake of Mn, like that of Ca… CONTINUE READING

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