Manganese-enhanced magnetic resonance imaging (MEMRI) of mouse brain development.

  title={Manganese-enhanced magnetic resonance imaging (MEMRI) of mouse brain development.},
  author={Youssef Zaim Wadghiri and Jeffrey A Blind and Xiaohong Duan and Clement Moreno and Xin Yu and Alexandra L. Joyner and Daniel H. Turnbull},
  journal={NMR in biomedicine},
  volume={17 8},
Given the importance of genetically modified mice in studies of mammalian brain development and human congenital brain diseases, MRI has the potential to provide an efficient in vivo approach for analyzing mutant phenotypes in the early postnatal mouse brain. The combination of reduced tissue contrast at the high magnetic fields required for mice, and the changing cellular composition of the developing mouse brain make it difficult to optimize MRI contrast in neonatal mouse imaging. We have… CONTINUE READING