Manganese-enhanced MRI of the optic visual pathway and optic nerve injury in adult rats.

@article{Thuen2005ManganeseenhancedMO,
  title={Manganese-enhanced MRI of the optic visual pathway and optic nerve injury in adult rats.},
  author={Marte Thuen and Trond E. Singstad and Tina Bugge Pedersen and Olav Haraldseth and Martin Foster Berry and Axel Sandvig and Christian Brekken},
  journal={Journal of magnetic resonance imaging : JMRI},
  year={2005},
  volume={22 4},
  pages={
          492-500
        }
}
PURPOSE To evaluate manganese (Mn2+)-enhanced MRI in a longitudinal study of normal and injured rat visual projections. MATERIALS AND METHODS MRI was performed 24 hours after unilateral intravitreal injection of MnCl2 (150 nmol) into adult Fischer rats that were divided into four groups: 1) controls (N = 5), 2) dose-response (N = 10, 0.2-200 nmol), 3) time-response with repeated MRI during 24-168 hours post injection (N = 4), and 4) optic nerve crush (ONC) immediately preceding the MnCl2… CONTINUE READING
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