Manganese-enhanced MRI of human choroidal melanoma xenografts.

  title={Manganese-enhanced MRI of human choroidal melanoma xenografts.},
  author={Rod D. Braun and Marius Gradianu and Kerry S. Vistisen and Robin L Roberts and Bruce A. Berkowitz},
  journal={Investigative ophthalmology & visual science},
  volume={48 3},
PURPOSE To test the hypothesis that the structure and function of an experimental human choroidal melanoma xenograft and neighboring non-tumor-bearing retina can be simultaneously assessed by using manganese-enhanced MRI (MEMRI). METHODS Spheroids grown from the human choroidal melanoma cell line C918 were implanted in the superior suprachoroidal space of 11 WAG/Nij-rnu nude rats. Two weeks later, MRI data were collected 4 hours after intraperitoneal injection of saline or MnCl(2), an MRI… CONTINUE READING