Manganese-enhanced MRI in a rat model of Parkinson's disease.

  title={Manganese-enhanced MRI in a rat model of Parkinson's disease.},
  author={Galit Pelled and Hagai Bergman and Tamir Ben-Hur and Gadi Goelman},
  journal={Journal of magnetic resonance imaging : JMRI},
  volume={26 4},
PURPOSE To measure intra- and inter-hemispheric connectivity within the basal ganglia (BG) nuclei in healthy and in unilateral 6-hydroxydopamine (6-OHDA) Parkinson disease rat model in order to test the BG interhemispheric connectivity hypothesis. MATERIAL AND METHODS The manganese-enhanced MRI (MEMRI) method with direct injection of manganese chloride into the entopeduncular (EP), substantia nigra (SN), and the Habenula nuclei in unilateral 6-OHDA (N = 22) and sham-operated (N = 16) rat… CONTINUE READING
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