Manganese-enhanced MRI enables longitudinal tracking of transplanted stem cell viability in the murine myocardium

@inproceedings{Dash2014ManganeseenhancedME,
  title={Manganese-enhanced MRI enables longitudinal tracking of transplanted stem cell viability in the murine myocardium},
  author={Rajesh C. Dash and Aditya Subramanian and Yuka Matsuura and Il Suk Sohn and Ting-Yuan Yeh and Michael V. McConnell and Joseph C Wu and Phillip C Yang},
  booktitle={Journal of Cardiovascular Magnetic Resonance},
  year={2014}
}
Background Stem cell therapy in the heart is limited by an inability to track transplanted cell survival. To address this limitation, we used human amnion-derived mesenchymal stem cells (hAMSCs), which exhibit longer in vivo survival, and Manganese (Mn2+)-Enhanced MRI (MEMRI), which enters live stem cells to augment T1 signal. We tested Mn2+ pre-labeling of hAMSCs in vitro and whether MEMRI would detect hAMSC survival in mouse myocardium in vivo. Methods hAMSCs were isolated from human… CONTINUE READING