Manganese enhanced MRI detects mossy fiber sprouting rather than neurodegeneration, gliosis or seizure-activity in the epileptic rat hippocampus

@article{Immonen2008ManganeseEM,
  title={Manganese enhanced MRI detects mossy fiber sprouting rather than neurodegeneration, gliosis or seizure-activity in the epileptic rat hippocampus},
  author={Riikka J. Immonen and Irina Kharatishvili and Alejandra Sierra and Christine Einula and Asla Pitk{\"a}nen and Olli Gr{\"o}hn},
  journal={NeuroImage},
  year={2008},
  volume={40},
  pages={1718-1730}
}
We tested a hypothesis that manganese enhanced magnetic resonance imaging (MEMRI) after systemic injection of MnCl(2) could detect axonal sprouting in the hippocampus following kainate (KA) induced status epilepticus (SE). MEMRI was performed at 3 h, 25 h, 4 days, and 2 months post-SE. To assess the contribution of various cellular alterations that occur in parallel with sprouting to the MEMRI signal, we sacrificed animals for histology at 4 days and 2 months post-SE. Neurodegeneration was… CONTINUE READING
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