Manganese disturbs metal and protein homeostasis in Caenorhabditis elegans.

@article{Angeli2014ManganeseDM,
  title={Manganese disturbs metal and protein homeostasis in Caenorhabditis elegans.},
  author={Suzanne Angeli and Tracy Barhydt and Ross Jacobs and David W Killilea and Gordon J. Lithgow and Julie K Andersen},
  journal={Metallomics : integrated biometal science},
  year={2014},
  volume={6 10},
  pages={1816-23}
}
Parkinson's disease (PD) is a debilitating motor and cognitive neurodegenerative disorder for which there is no cure. While aging is the major risk factor for developing PD, clear environmental risks have also been identified. Environmental exposure to the manganese (Mn) metal is a prominent risk factor for developing PD and occupational exposure to high levels of Mn can cause a syndrome known as manganism, which has symptoms that closely resemble PD. In this study, we developed a model of… CONTINUE READING