Manganese distribution across the blood-brain barrier. I. Evidence for carrier-mediated influx of managanese citrate as well as manganese and manganese transferrin.

@article{Crossgrove2003ManganeseDA,
  title={Manganese distribution across the blood-brain barrier. I. Evidence for carrier-mediated influx of managanese citrate as well as manganese and manganese transferrin.},
  author={Janelle S. Crossgrove and David D. Allen and Bonny L. Bukaveckas and Susan S Rhineheimer and Robert A. Yokel},
  journal={Neurotoxicology},
  year={2003},
  volume={24 1},
  pages={
          3-13
        }
}
Manganese (Mn) is an essential element and a neurotoxicant. Regulation of Mn movement across the blood-brain barrier (BBB) contributes to whether the brain Mn concentration is functional or toxic. In plasma, Mn associates with water, small molecular weight ligands and proteins. Mn speciation may influence the kinetics of its movement through the BBB. In the present work, the brain influx rates of 54Mn2+, 54Mn citrate and 54Mn transferrin (54Mn Tf) were determined using the in situ brain… CONTINUE READING
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