Manganese deposition in basal ganglia structures results from both portal-systemic shunting and liver dysfunction.

@article{Rose1999ManganeseDI,
  title={Manganese deposition in basal ganglia structures results from both portal-systemic shunting and liver dysfunction.},
  author={Christopher Rose and Roger F. Butterworth and Joseph Zayed and Louise Normandin and Kathy Todd and Adrianna Michalak and Laurent Spahr and Pierre Michel Huet and Gilles T Pomier-Layrargues},
  journal={Gastroenterology},
  year={1999},
  volume={117 3},
  pages={640-4}
}
BACKGROUND & AIMS Manganese (Mn) deposition could be responsible for the T(1)-weighted magnetic resonance signal hyperintensities observed in cirrhotic patients. These experiments were designed to assess the regional specificity of the Mn increases as well as their relationship to portal-systemic shunting or hepatobiliary dysfunction. METHODS Mn concentrations were measured in (1) brain samples from basal ganglia structures (pallidum, putamen, caudate nucleus) and cerebral cortical structures… CONTINUE READING
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