Manganese-catalyzed oligomerizations of nucleotide analogs

  title={Manganese-catalyzed oligomerizations of nucleotide analogs},
  author={Jeroen Visscher and Alan W. Schwartz},
  journal={Journal of Molecular Evolution},
The synthesis of pyrophosphate-linked oligomers from the bis-phosphoimidazolides of deoxyadenosine and deoxyguanosine, as well as from acyclic analogs of these nucleosides, is catalyzed much more effectively by Mn(II) than by Mg(II). The presence of Mn(II) reduces the extent of cyclization of the monomer-bis-phosphoimidazolide and thereby increases the yields of oligomeric products. The Mn(II)-catalyzed oligomerization is less sensitive to the presence of a complementary polynucleotide template… CONTINUE READING