Manganese binds to Clostridium difficile Fbp68 and is essential for fibronectin binding.

@article{Lin2011ManganeseBT,
  title={Manganese binds to Clostridium difficile Fbp68 and is essential for fibronectin binding.},
  author={Yi-Pin Lin and Chih-Jung Kuo and Xhelil Koleci and Sean Mcdonough and Yung-fu Chang},
  journal={The Journal of biological chemistry},
  year={2011},
  volume={286 5},
  pages={
          3957-69
        }
}
Clostridium difficile is an etiological agent of pseudomembranous colitis and antibiotic-associated diarrhea. Adhesion is the crucial first step in bacterial infection. Thus, in addition to toxins, the importance of colonization factors in C. difficile-associated disease is recognized. In this study, we identified Fbp68, one of the colonization factors that bind to fibronectin (Fn), as a manganese-binding protein (K(D) = 52.70 ± 1.97 nM). Furthermore, the conformation of Fbp68 changed… CONTINUE READING

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