Manganese and copper-zinc superoxide dismutases in the human olfactory mucosa: increased immunoreactivity in Alzheimer's disease.

Superoxide dismutases are the cell's major enzymatic defenses against cytotoxic reactive oxygen species and oxidative stress. Reactive oxygen species, which induce the expression of these enzymes, have been implicated in the neurodegeneration associated with Alzheimer's disease (AD), and individuals with AD exhibit early, severe deficits in olfactory… CONTINUE READING