Manganese and antibiotic biosynthesis. III. The site of manganese control of patulin production in Penicillium urticae.

Although manganese had been shown to be an essential requirement for patulin biosynthesis, its site of action was unknown. Four possibilities were considered. A manganese requirement for the second pathway enzyme, a decarboxylase, was discounted since mid and late pathway intermediates were not converted to patulin in manganese-deficient cultures. A major… CONTINUE READING