Manganese action in brain function

  title={Manganese action in brain function},
  author={Atsushi Takeda},
  journal={Brain Research Reviews},
  • A. Takeda
  • Published 31 January 2003
  • Biology
  • Brain Research Reviews
[Essential trace metals and brain function].
  • A. Takeda
  • Biology, Chemistry
    Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan
  • 2004
It is reported that the brain transferrin concentration is decreased in neurodegenerative diseases such as Alzheimer's disease and Parkinson's Disease and that brain iron metabolism is also altered.
Analysis of Brain Function and Prevention of Brain Diseases: the Action of Trace Metals
Dietary zinc deficiency affects zinc homeostasis in the brain, followed by an enhanced excitotoxicity of glutamate in the hippocampus, and Transferrin may be involved in the physiologic transport of iron and manganese into the brain and their utilization there.
Manganese Flux Across the Blood–Brain Barrier
  • R. Yokel
  • Biology, Chemistry
    NeuroMolecular Medicine
  • 2009
Owing to carrier-mediated brain Mn influx and diffusion-mediated efflux, slow brain Mn clearance and brain Mn accumulation with repeated excess exposure would be predicted, and have been reported, which may render the brain susceptible to Mn-induced neurotoxicity from excessive Mn exposure.
Manganese Control of Glutamate Transporters' Gene Expression.
The mechanisms of Mn-induced gene regulation of glutamate transporters at the transcriptional level and their role in Mn toxicity are reviewed.
GLAST Activity is Modified by Acute Manganese Exposure in Bergmann Glial Cells
The results favor the notion of a direct effect of manganese on glial cells, this in turn alters their coupling with neurons and might lead to changes in glutamatergic transmission.
Manganese Neurotoxicity
Evidence for the role of oxidative stress in the progression of manganism and the importance of investigating the human health effects of using the controversial compound, methylcyclopentadienyl manganese tricarbonyl (MMT), in gasoline to increase octane is reviewed.
Brain manganese and the balance between essential roles and neurotoxicity
Gaps in understanding of the molecular and biochemical mechanisms underlying Mn homeostasis and neurotoxicity are identified and changes in the brain leading to physiological effects throughout the body and vice versa are identified.
Manganese neurotoxicity: behavioral disorders associated with dysfunctions in the basal ganglia and neurochemical transmission
The collected data from recent available studies in humans and experimental animal models provide new information about the mechanisms by which Mn affects behavior, neurotransmitters, and basal ganglia function observed in manganism.
The Importance of Trace Elements for Neurological Function
This chapter will focus on iron, manganese, copper, and zinc, dietary trace metals required for numerous important processes in the CNS, roles in brain development, effects on neurotransmitter biology, consequences of metal deficiency and toxicity, and applications to health and disease.


Manganese uptake into rat brain during development and aging
The results suggest that Mn is required in a high amount during infancy and that a sufficient Mn supply is critical for normal brain development.
Manganese neurotoxicity: a model for free radical mediated neurodegeneration?
Investigations in the laboratory suggest that neurotoxicity of manganese is an exaggeration of function in normal neuronal homeostasis, and that this effect may arise preferentially in the substantia nigra, where neuromelanin is formed nonenzymatically by autoxidation of dopamine.
Regulation of heme and drug metabolism activities in the brain by manganese.
  • M. Qato, M. Maines
  • Biology, Chemistry
    Biochemical and biophysical research communications
  • 1985
Impaired Excitatory Transmission in the Striatum of Rats Chronically Intoxicated with Manganese
It is concluded that hyperactivity of corticostriatal neurons, rather than increased postsynaptic sensitivity to glutamate, accounts for the abnormal excitation of striatal neurons in the course of Mn intoxication.
Trace Metal Transport at the Blood-Brain Barrier
A number of trace metals are normally present within the central nervous system (CNS), and may have effects on its function. Several, e.g., zinc, iron, copper and manganese are essential for normal