Manganese accumulation in striatum of mice exposed to toxic doses is dependent upon a functional dopamine transporter.

@article{Erikson2005ManganeseAI,
  title={Manganese accumulation in striatum of mice exposed to toxic doses is dependent upon a functional dopamine transporter.},
  author={Keith M. Erikson and Carrie E John and Sara R Jones and Michael Aschner},
  journal={Environmental toxicology and pharmacology},
  year={2005},
  volume={20 3},
  pages={390-4}
}
The objective of this study was to determine the importance of the dopamine transporter (DAT) in manganese transport. Excessive manganese exposure is associated with a neurotoxicological disease known as manganism characterized by a specific accumulation of manganese in dopamine-rich brain regions. It has been hypothesized that the DAT mediates this specific transport, but its role in manganese neurotoxicity has not been directly examined. We examined brain tissues from manganese-exposed… CONTINUE READING

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