Manganese Neurotoxicity: An Update of Pathophysiologic Mechanisms

@article{Normandin2004ManganeseNA,
  title={Manganese Neurotoxicity: An Update of Pathophysiologic Mechanisms},
  author={L. Normandin and A. Hazell},
  journal={Metabolic Brain Disease},
  year={2004},
  volume={17},
  pages={375-387}
}
The central nervous system, and the basal ganglia in particular, is an important target in manganese neurotoxicity, a disorder producing neurological symptoms similar to that of Parkinson's disease. Increasing evidence suggests that astrocytes are a site of early dysfunction and damage; chronic exposure to manganese leads to selective dopaminergic dysfunction, neuronal loss, and gliosis in basal ganglia structures together with characteristic astrocytic changes known as Alzheimer type II… Expand
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