Manganese-Enhanced Magnetic Resonance Imaging Enables In Vivo Confirmation of Peri-Infarct Restoration Following Stem Cell Therapy in a Porcine Ischemia–Reperfusion Model

@article{Dash2015ManganeseEnhancedMR,
  title={Manganese-Enhanced Magnetic Resonance Imaging Enables In Vivo Confirmation of Peri-Infarct Restoration Following Stem Cell Therapy in a Porcine Ischemia–Reperfusion Model},
  author={R. Dash and P. Kim and Y. Matsuura and F. Ikeno and Scott Metzler and N. Huang and Jennifer K Lyons and P. Nguyen and X. Ge and C. Wong Po Foo and M. McConnell and J. Wu and A. Yeung and Phillip Harnish and P. Yang},
  journal={Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease},
  year={2015},
  volume={4}
}
  • R. Dash, P. Kim, +12 authors P. Yang
  • Published 2015
  • Medicine
  • Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
  • Background The exact mechanism of stem cell therapy in augmenting the function of ischemic cardiomyopathy is unclear. In this study, we hypothesized that increased viability of the peri-infarct region (PIR) produces restorative benefits after stem cell engraftment. A novel multimodality imaging approach simultaneously assessed myocardial viability (manganese-enhanced magnetic resonance imaging [MEMRI]), myocardial scar (delayed gadolinium enhancement MRI), and transplanted stem cell engraftment… CONTINUE READING
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