• DOI:10.1161/JAHA.115.002044
Corpus ID: 1778692

Manganese-Enhanced Magnetic Resonance Imaging Enables In Vivo Confirmation of Peri-Infarct Restoration Following Stem Cell Therapy in a Porcine Ischemia–Reperfusion Model

@article{Dash2015ManganeseEnhancedMR,
  title={Manganese-Enhanced Magnetic Resonance Imaging Enables In Vivo Confirmation of Peri-Infarct Restoration Following Stem Cell Therapy in a Porcine Ischemia–Reperfusion Model},
  author={R. Dash and P. Kim and Y. Matsuura and F. Ikeno and Scott Metzler and N. Huang and Jennifer K Lyons and P. Nguyen and X. Ge and C. Wong Po Foo and M. McConnell and J. Wu and A. Yeung and Phillip Harnish and P. Yang},
  journal={Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease},
  year={2015},
  volume={4}
}

R. Dash, P. Kim, +12 authors P. Yang

Published 2015

Medicine

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease

Background The exact mechanism of stem cell therapy in augmenting the function of ischemic cardiomyopathy is unclear. In this study, we hypothesized that increased viability of the peri-infarct region (PIR) produces restorative benefits after stem cell engraftment. A novel multimodality imaging approach simultaneously assessed myocardial viability (manganese-enhanced magnetic resonance imaging [MEMRI]), myocardial scar (delayed gadolinium enhancement MRI), and transplanted stem cell engraftment… CONTINUE READING

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