Manduca sexta hemolymph proteinase 21 activates prophenoloxidase-activating proteinase 3 in an insect innate immune response proteinase cascade.

@article{Gorman2007ManducaSH,
  title={Manduca sexta hemolymph proteinase 21 activates prophenoloxidase-activating proteinase 3 in an insect innate immune response proteinase cascade.},
  author={Maureen J. Gorman and Yang Wang and Haobo Jiang and Michael R. Kanost},
  journal={The Journal of biological chemistry},
  year={2007},
  volume={282 16},
  pages={11742-9}
}
Melanization, an insect immune response, requires a set of hemolymph proteins including pathogen recognition proteins that initiate the response, a cascade of mostly unknown serine proteinases, and phenoloxidase. Until now, only initial and final proteinases in the pathways have been conclusively identified. Four such proteinases have been purified from the larval hemolymph of Manduca sexta: hemolymph proteinase 14 (HP14), which autoactivates in the presence of microbial surface components, and… CONTINUE READING

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